The risk of the mother or baby contracting HIV disease from this procedure is less than it would be if a pregnancy were attempted by using unprotected sex or sperm from untested specimens. As of September 2014, no one using tested semen has become infected.

The risks of the infertility procedures themselves will be explained by the gynecologists and infertility specialists.

Although no one has become infected following the use of tested sperm, the SPAR protocol includes HIV antibody testing at 3 weeks, 3 months and 6 months after each and every pregnancy attempt.